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Dengue > Drug Therapy Author: Suranjith L. Seneviratne, MD, DPhil, MRCP, FRCPath; Panduka Karunanayake, MD, MRCP; Bandula Wijesiriwardena, MD, FRCP, FCCP, FCMSA, FRACP, FACP
Editorial changes - 2011-12-08
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Rationale:

  • There is no specific antiviral drug therapy for dengue.
  • Different drugs can be used to manage symptoms and treat complications.

Evidence:

  • A randomized, controlled study compared treatment with intravenous immunoglobulin (n = 15) vs. no treatment (n = 16) to determine whether a high dose of intravenous immunoglobulin is effective in hastening recovery from thrombocytopenia in patients with secondary dengue virus infection. No significant difference was found in the baseline demographic data between the two groups. No adverse effect of intravenous immunoglobulin was observed, but no effect in hastening the recovery of platelet counts was found in patients with secondary dengue virus infection (108).

Comments:

  • Drugs are only useful in patients with dengue to manage symptoms and treat complications, such as liver failure, heart failure, and superadded infections.

FAQs
Bandula Wijesiriwardena, MD, FRCP, FCCP, FCMSA, FRACP, FACP has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Panduka Karunanayake, MD, MRCP has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Suranjith L. Seneviratne, MD, DPhil, MRCP, FRCPath has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Deborah Korenstein, MD, FACP, Co-Editor, PIER, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Richard B. Lynn, MD, FACP, Co-Editor, PIER, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.

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