Malaria Author: Rick M. Fairhurst, MD, PhD; Thomas E. Wellems, MD, PhD
Editorial changes - 2012-05-10
Author information and module status
Prevention
Screening
Diagnosis
Consultation for Diagnosis
Hospitalization
Non-drug Therapy
Drug Therapy
Patient Education
Consultation for Management
Follow-up

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Clinical Information
Guideline
   World Health Organization
 Guidelines for the treatment of malaria
Article
   Annals of Internal Medicine
 Failure of doxycycline as a causal prophylactic agent against Plasmodium falciparum malaria in healthy nonimmune volunteers
 Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers
 Mefloquine compared with doxycycline for the prophylaxis of malaria in Indonesian soldiers. A randomized, double-blind, placebo-controlled trial
 Primaquine prophylaxis against malaria in nonimmune Colombian soldiers: efficacy and toxicity. A randomized, double-blind, placebo-controlled trial
 Advancing the war on malaria
   Archives of Internal Medicine
 Etiology and outcome of fever after a stay in the tropics
   BMJ
 Rapid testing for malaria in settings where microscopy is available and peripheral clinics where only presumptive treatment is available: a randomised controlled trial in Ghana.
 WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study.
 Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trial.
   British Medical Journal
 Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study
 Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: five year prospective study
 Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
 Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial
 Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study
 Cluster randomised trial of intermittent preventive treatment for malaria in infants in area of high, seasonal transmission in Ghana
 Treatment of paediatric malaria during a period of drug transition to artemether-lumefantrine in Zambia: cross sectional study
 Cost effectiveness analysis of strategies to combat malaria in developing countries
 Severe placental malaria and maternal shortness, thinness, and small skeletal size in rural Congo: cohort study
 Safety and efficacy of rectal compared with intramuscular quinine for the early treatment of moderately severe malaria in children: randomised clinical trial
 Malaria: an update on treatment of adults in non-endemic countries
 Severe malaria in children in Yemen: two site observational study
 Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial
 Plant based insect repellent and insecticide treated bed nets to protect against malaria in areas of early evening biting vectors: double blind randomised placebo controlled clinical trial in the Bolivian Amazon
 Reduced in-hospital mortality after improved management of children under 5 years admitted to hospital with malaria: randomised trial
 The impact of response to the results of diagnostic tests for malaria: cost-benefit analysis
 Imported malaria and high risk groups: observational study using UK surveillance data 1987-2006
 Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
   Clinical Infectious Diseases
 Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria
   Journal of the American Medical Association
 Sustainability of reductions in malaria transmission and infant mortality in western Kenya with use of insecticide-treated bednets: 4 to 6 years of follow-up
 An outbreak of malaria in US Army Rangers returning from Afghanistan
 Association of transmission intensity and age with clinical manifestations and case fatality of severe Plasmodium falciparum malaria
 Prevention of malaria in long-term travelers
 Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial
 Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial
 Hemoglobin variants and disease manifestations in severe falciparum malaria
 Improved diagnostic testing and malaria treatment practices in Zambia
 Estimating the number of insecticide-treated nets required by African households to reach continent-wide malaria coverage targets
 Controversies and misconceptions in malaria chemoprophylaxis for travelers
   Lancet
 Potential effect of climate change on malaria transmission in Africa
 Artesunate combinations for treatment of malaria: meta-analysis
 Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial
 Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria
 Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial
 Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
 Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial
 Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial
 Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial
 Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial
 Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
 Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6
 Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial
 Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial
 Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial
 Climate change and human health: present and future risks
 Effect of co-trimoxazole prophylaxis, antiretroviral therapy, and insecticide-treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study
 Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison
 Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial
 Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial
 Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison
 Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial
 Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial
 Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial
 Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial
 Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial
 Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
 Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
 Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials.
 Equity and adequacy of international donor assistance for global malaria control: an analysis of populations at risk and external funding commitments.
 Adult and child malaria mortality in India: a nationally representative mortality survey.
 Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.
 Prereferral rectal artesunate for treatment of severe childhood malaria: a cost-effectiveness analysis.
 Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study.
   New England Journal of Medicine
 Two worlds of malaria
 Genomics and malaria control
 Return of chloroquine antimalarial efficacy in Malawi
 Pyruvate kinase deficiency and malaria
 Artesunate for the treatment of severe falciparum malaria
 Safety and immunogenicity of RTS,S/AS02D malaria vaccine in infants
 A trial of combination antimalarial therapies in children from Papua New Guinea
 Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
 Artemisinin resistance in Plasmodium falciparum malaria
 Protection against a malaria challenge by sporozoite inoculation
Review
   Annals of Internal Medicine
 Meta-analysis: accuracy of rapid tests for malaria in travelers returning from endemic areas
   Annals of Pharmacotherapy
 Atovaquone-proguanil for prophylaxis and treatment of malaria
   Archives of Internal Medicine
 Challenges in the prevention, diagnosis, and treatment of malaria in human immunodeficiency virus infected adults in sub-saharan Africa
   British Medical Journal
 Severe life threatening malaria in endemic areas
 Traditional herbal medicines for malaria
 Preventing malaria in travellers
   Cochrane Database of Systematic Reviews
 Artemisinin derivatives for treating uncomplicated malaria
 Steroids for treating cerebral malaria
 Blood transfusion for treating malarial anaemia
 Antipyretic measures for treating fever in malaria
 Routine anticonvulsants for treating cerebral malaria
 Amodiaquine for treating malaria
 Iron chelating agents for treating malaria
 Insecticide-treated bednets and curtains for preventing malaria
 High first dose quinine regimen for treating severe malaria
 Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for treating uncomplicated malaria
 Drugs for preventing malaria-related illness in pregnant women
 Malaria chemoprophylaxis in sickle cell disease
 WITHDRAWN: Vaccines for preventing malaria
 WITHDRAWN: Artemether-lumefantrine for treating uncomplicated falciparum malaria
 WITHDRAWN: Mefloquine for preventing malaria in non-immune adult travellers
 Drugs for treating uncomplicated malaria in pregnant women
 Artemisinin-based combination therapy for treating uncomplicated malaria
   Cochrane Library
 (Cochrane Review)
   Critical Care
 Clinical review: severe malaria
   Drugs
 Atovaquone/proguanil: a review of its use for the prophylaxis of Plasmodium falciparum malaria
   Infectious Diseases
 What are the effects of treatments?
 What are the effects of medical treatment for complicated falciparum malaria in non-pregnant people?
   Jama
 Does this patient have malaria?
   Journal of the American Medical Association
 Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children
 Treatment of malaria in the United States: a systematic review
 Rectal administration of artemisinin derivatives for the treatment of malaria
 Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review
   Lancet
 Malaria
 A new global malaria eradication strategy
 Ranking of elimination feasibility between malaria-endemic countries.
 Costs and financial feasibility of malaria elimination.
 Operational strategies to achieve and maintain malaria elimination.
 Shrinking the malaria map: progress and prospects.
   New England Journal of Medicine
 Effectiveness of antimalarial drugs
 Clinical practice. Malaria prevention in short-term travelers
Commentary
   ACP Journal Club
      Travel
 2007 - Review: Flight times greater than 8 hours and the presence of risk factors for VTE increase travel-related VTE

Patient Information
Web
 American Academy of Family Physicians: Malaria: How to Prevent It
 Centers for Disease Control and Prevention: Malaria
 World Health Organization: Malaria
FAQs | Patient Information
Harry Tagbor, MBChB, DrPH, editorial consultant, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Rick M. Fairhurst, MD, PhD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Thomas E. Wellems, MD, PhD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Deborah Korenstein, MD, FACP, Co-Editor, PIER, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Richard B. Lynn, MD, FACP, Co-Editor, PIER, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.


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