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Rationale:
- Identifying causes of obesity can reveal diseases for which specific treatment is needed or may become available.
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Evidence:
- Hypothalamic injury can cause obesity and is manifested by symptoms of CNS swelling, endocrine dysfunction, or hypothalamic
symptoms (318).
- Cushing's disease is associated with striae, hypertension, and central fat distribution (319; 320).
- Polycystic ovary disease is associated with dysmenorrhea, hirsutism, anovulatory cycles, and obesity (321; 322).
- Hypothyroidism can lead to weight gain (323).
- Pseudohypoparathyroidism has round facies and mild obesity (324).
- Several genetic syndromes, such as Prader-Willi syndrome, have phenotypic features that make them recognizable, but most require
genetic analysis (129; 325).
- The metabolic syndrome is a defined entity that is present when three of the five characteristics in the table Clinical Features of the Metabolic Syndrome are present (236).
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Comments:
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George A. Bray, MD, is a speaker for Eli Lilly, Amylin Corp., and Merck & Co., received grants from Merck & Co., and Takeda Pharmaceuticals; and
has consulted for Sanofi-Aventis, Merck, and Amylin.
Steven E. Weinberger, MD, FACP, Acting Editor, PIER, has stock holdings in Glaxosmithkline and Abbott.
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The information included herein should never be used as a substitute
for clinical judgment and does not represent an official position of
ACP. Because all PIER modules are updated regularly, printed web pages
or PDFs may rapidly become obsolete. Therefore, PIER users should
compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2009 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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Obesity
> Diagnosis
