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Rationale:
- For allergic patients, clindamycin is the preferred choice for either MSSA or MRSA infection, if sensitive. Unfortunately,
clindamycin resistance is increasing in community-onset staphylococcal infections, making additional options necessary.
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Evidence:
- Parenteral antimicrobials active against MSSA are traditionally used in hospitalized patients. Oral antimicrobials may be
comparable to intravenous ones, but they have not been adequately tested in comparative trials in patients with cellulitis
and soft tissue infection with the exception of linezolid (121).
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Comments:
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Dennis L. Stevens, PhD, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Lawrence J. Eron, MD, FACP has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Steven E. Weinberger, MD, FACP, Acting Editor, PIER, has stock holdings in Glaxosmithkline and Abbott.
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The information included herein should never be used as a substitute
for clinical judgment and does not represent an official position of
ACP. Because all PIER modules are updated regularly, printed web pages
or PDFs may rapidly become obsolete. Therefore, PIER users should
compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2009 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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Cellulitis and Soft Tissue Infections
> Drug Therapy
