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Rationale:
- Infections due to human bites are frequently polymicrobial and deeper than originally suspected. Because they usually involve
the hand (clenched fist), infection may develop in bone and tendon sheaths; therefore, hospitalization is recommended and
surgical evaluation and/or debridement may be necessary.
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Evidence:
- Infections from human bites are most commonly caused by Eikenella corrodens, anaerobes, and viridans streptococci (115; 17). Ampicillin/sulbactam has good activity against all these organisms (18; 16).
- Eikenella corrodens is resistant to first-generation cephalosporins and clindamycin (18; 16).
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Comments:
- Infections due to human bites can rapidly become fulminant and clinicians should hospitalize patients or at least observe
them closely for evidence of extension of infection into the deep tissues beneath the bite.
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Dennis L. Stevens, PhD, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Lawrence J. Eron, MD, FACP has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
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The information included herein should never be used as a substitute
for clinical judgment and does not represent an official position of
ACP. Because all PIER modules are updated regularly, printed web pages
or PDFs may rapidly become obsolete. Therefore, PIER users should
compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2008 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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Cellulitis and Soft Tissue Infections
> Drug Therapy
