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Rationale:
- Patients with diabetic foot ulcers can develop severe limb-threatening infection.
- Because of their peripheral neuropathy, diabetic patients may not be aware of an infected plantar ulcer.
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Evidence:
- Prevention of infection in diabetic patients requires meticulous care, preferably by a multidisciplinary foot-care team (15).
- A double-blind, controlled trial compared topically applied pexiganan cream with orally administered ofloxacin for the treatment
of mildly infected diabetic foot ulcers. When data from two trials were combined, there was equivalence between the two respective
regimens (85% and 90% clinical improvement and 2% and 3% amputation rates) (16).
- Tinea pedis may be a predisposing factor for cellulitis of the lower extremities (17).
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Comments:
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Dennis L. Stevens, PhD, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Lawrence J. Eron, MD, FACP has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Darren B. Taichman, MD, PhD, Editor, PIER, has received grant support from Actelion Pharmaceuticals Ltd , and honoraria for
continuing medical education grand rounds and lectures given.
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The information included herein should never be used as a substitute
for clinical judgment and does not represent an official position of
ACP. Because all PIER modules are updated regularly, printed web pages
or PDFs may rapidly become obsolete. Therefore, PIER users should
compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2010 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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Cellulitis and Soft Tissue Infections
> Prevention
