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Rationale:
- Some authors have warned that benzodiazepines given in the acute aftermath of a traumatic stressor may worsen long-term outcomes
for patients with posttraumatic stress symptoms.
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Evidence:
- Suppression of acute posttraumatic stress reactions with benzodiazepines may not prevent PTSD. An uncontrolled trial found
no decrease in posttraumatic stress symptoms or startle reactions among individuals given benzodiazepines (4).
- An expert consensus panel ranked benzodiazepines as a second-line treatment choice (1).
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Comments:
- Patients and physicians may find it difficult to follow this counterintuitive treatment recommendation. It remains an area
of controversy in the literature.
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Jeffrey P. Staab, MD, MS, is a consultant for Eli Lilly, Forest Laboratories, received honorarium from Abbott Laboratories, received grants from GlaxoSmithKline,
Pfizer. Michael Roy, MD, editorial consultant, received honorarium from PFizer.
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The information included herein should never be used as a substitute
for clinical judgment and does not represent an official position of
ACP. Because all PIER modules are updated regularly, printed web pages
or PDFs may rapidly become obsolete. Therefore, PIER users should
compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2008 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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Posttraumatic Stress Disorder
> Prevention
