Diabetes Mellitus, Type 2 Author: Sandeep Vijan, MD
Editorial changes - 2010-01-20
Author information and module status
Prevention
Screening
Diagnosis
Consultation for Diagnosis
Hospitalization
Non-drug Therapy
Drug Therapy
Patient Education
Consultation for Management
Follow-up

Tables
Figures
References
Glossary
What's New
Patient Information
Additional Resources
Tools

Quality Measures Quality Measures
Additional Resources

Clinical Information
Guideline
   American Association of Clinical Endocrinologists
 Medical guidelines for clinical practice for the management of diabetes mellitus
   American College of Endocrinology
 American College of Endocrinology consensus statement on the diagnosis and management of pre-diabetes in the continuum of hyperglycemia—when do the risks of diabetes begin?
   Annals of Internal Medicine
 Lipid control in the management of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians
 Pharmacologic lipid-lowering therapy in type 2 diabetes mellitus: background paper for the American College of Physicians
 The evidence base for tight blood pressure control in the management of type 2 diabetes mellitus
 Treatment of hypertension in type 2 diabetes mellitus: blood pressure goals, choice of agents, and setting priorities in diabetes care
 Screening for type 2 diabetes mellitus in adults: recommendations and rationale
 Screening adults for type 2 diabetes: a review of the evidence for the U.S. Preventive Services Task Force
 Glycemic control and type 2 diabetes mellitus: the optimal hemoglobin A1c targets. A guidance statement from the American College of Physicians
 Screening for type 2 diabetes mellitus in adults: U.S. Preventive Services Task Force recommendation statement
 Screening adults for type 2 diabetes: a review of the evidence for the U.S. Preventive Services Task Force
   British Medical Journal
 Management of type 2 diabetes: summary of updated NICE guidance
 Newer agents for blood glucose control in type 2 diabetes: summary of NICE guidance
   Diabetes Care
 Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy
 International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes
   Journal of the American Geriatrics Society
 Guidelines for improving the care of the older person with diabetes mellitus
Article
   Acta Ophthalmologica Scandinavica
 Cataract surgery on diabetic patients. A prospective evaluation of risk factors and complications
   American Journal of Epidemiology
 Cigarette smoking and risk of type 2 diabetes mellitus among middle-aged and elderly Japanese men and women
   American Journal of Medicine
 The effect of interventions to prevent cardiovascular disease in patients with type 2 diabetes mellitus
 Are calcium antagonists beneficial in diabetic patients with hypertension?
   American Journal of Ophthalmology
 Glitazone use associated with diabetic macular edema
   Annals of Internal Medicine
 Smoking, smoking cessation, and risk for type 2 diabetes mellitus: a cohort study
 Comorbidity affects the relationship between glycemic control and cardiovascular outcomes in diabetes: a cohort study
 The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial
 The association between quality of care and the intensity of diabetes disease management programs
 The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men
 Inhaled human insulin treatment in patients with type 2 diabetes mellitus
 Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States
 Physical activity and risk for cardiovascular events in diabetic women
 Dietary patterns and risk for type 2 diabetes mellitus in U.S. men
 Management of hypertension in patients with type 2 diabetes mellitus: guidelines based on current evidence
 Mixed hepatocellular-cholestatic liver injury after pioglitazone therapy
 A diabetes report card for the United States: quality of care in the 1990s
 Identification of persons at high risk for type 2 diabetes mellitus: do we need the oral glucose tolerance test?
 Metformin: an update
 Tests of glycemia for the diagnosis of type 2 diabetes mellitus
 Effect of a multivitamin and mineral supplement on infection and quality of life. A randomized, double-blind, placebo-controlled trial
 Cardiovascular outcomes in the Irbesartan Diabetic Nephropathy Trial of patients with type 2 diabetes and overt nephropathy
 Glimepiride combined with morning insulin glargine, bedtime neutral protamine hagedorn insulin, or bedtime insulin glargine in patients with type 2 diabetes. A randomized, controlled trial
 Effect of losartan on microalbuminuria in normotensive patients with type 2 diabetes mellitus. A randomized clinical trial
 Use of metabolic markers to identify overweight individuals who are insulin resistant
 Coffee consumption and risk for type 2 diabetes mellitus
 Clinical spectrum associated with hepatocyte nuclear factor-1β mutations
 The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial
 Coronary vasomotor abnormalities in insulin-resistant individuals
 Metabolic effects of rosiglitazone in HIV lipodystrophy: a randomized, controlled trial
 Screening for type 2 diabetes mellitus: a cost-effectiveness analysis
 The effectiveness of depression care management on diabetes-related outcomes in older patients
 Clinical implications of estimating equations for glomerular filtration rate
 Diabetes care quality in the Veterans Affairs Health Care System and commercial managed care: the TRIAD study
 Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk
 Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus
 Incidence of type 2 diabetes in the randomized multiple risk factor intervention trial
 The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance
 Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes
 The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial
 Impaired fasting glucose and cardiovascular outcomes in postmenopausal women with coronary artery disease
 Cost-effectiveness of full medicare coverage of angiotensin-converting enzyme inhibitors for beneficiaries with diabetes
 Clinical outcomes and cost-effectiveness of strategies for managing people at high risk for diabetes
 Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial
 Improvements in diabetes processes of care and intermediate outcomes: United States, 1988-2002
 Therapy modifications in response to poorly controlled hypertension, dyslipidemia, and diabetes mellitus
 The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults
 Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
 Mortality trends in men and women with diabetes, 1971 to 2000
 Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial
 Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial
 The role of clinical uncertainty in treatment decisions for diabetic patients with uncontrolled blood pressure
 Association of numeracy and diabetes control
 Diabetes and hearing impairment in the United States: audiometric evidence from the National Health and Nutrition Examination Survey, 1999 to 2004
 The effect of comorbid illness and functional status on the expected benefits of intensive glucose control in older patients with type 2 diabetes: a decision analysis
 Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women
 Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial
 Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
 Two risk-scoring systems for predicting incident diabetes mellitus in U.S. adults age 45 to 64 years
 Glycemic control in type 2 diabetes: time for an evidence-based about-face?
 Effect of candesartan on microalbuminuria and albumin excretion rate in diabetes: three randomized trials
 Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomized trial
 The net value of health care for patients with type 2 diabetes, 1997 to 2005
 Development and validation of a patient self-assessment score for diabetes risk
   Archives of Internal Medicine
 Socioeconomic status and trends in disparities in 4 major risk factors for cardiovascular disease among US adults, 1971-2002
 Prediction of coronary artery calcium in young adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA study
 Asymptomatic bacteriuria in women with diabetes mellitus: effect on renal function after 6 years of follow-up
 Risk factors of vitamin B(12) deficiency in patients receiving metformin
 Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus
 Effects of etanercept in patients with the metabolic syndrome
 Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate
 Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney disease
 Metabolic syndrome and the progression of carotid intima-media thickness in elderly women
 Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1
 Preemptive transplantation for patients with diabetes-related kidney disease
 Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke: the Framingham Offspring Study
 Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes
 Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohort
 Relationship of walking to mortality among US adults with diabetes
 Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women
 Smoking and risk of coronary heart disease among women with type 2 diabetes mellitus
 Sex differences in risk factors for incident type 2 diabetes mellitus: the MONICA Augsburg cohort study
 Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT)
 C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998
 Role of organizational factors in poor blood pressure control in patients with type 2 diabetes: the QuED Study Group-Quality of Care and Outcomes in Type 2 Diabetes
 A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents
 Sex differences in risk for coronary heart disease mortality associated with diabetes and established coronary heart disease
 The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial
 Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study
 Inhaled insulin provides improved glycemic control in patients with type 2 diabetes mellitus inadequately controlled with oral agents: a randomized controlled trial
 Retinal vascular changes and 20-year incidence of lower extremity amputations in a cohort with diabetes
 Inpatient to outpatient transfer of care in urban patients with diabetes: patterns and determinants of immediate postdischarge follow-up
 Optimal glycemic control in type 2 diabetes mellitus: fasting and postprandial glucose in context
 Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation
 Hemoglobin A1c level and future cardiovascular events among women
 Insulin therapy for critically ill hospitalized patients: a meta-analysis of randomized controlled trials
 Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies
 Trends in complexity of diabetes care in the United States from 1991 to 2000
 The diagnostic yield of a standardized approach to idiopathic sensory-predominant neuropathy
 Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus
 Dietary patterns, meat intake, and the risk of type 2 diabetes in women
 Impact of diabetes on mortality in patients with myocardial infarction and left ventricular dysfunction
 A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors
 Aspirin use among adults with diabetes: recent trends and emerging sex disparities
 The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up
 Impact of diabetes and previous myocardial infarction on long-term survival: 25-year mortality follow-up of primary screenees of the Multiple Risk Factor Intervention Trial
 A probabilistic model for predicting hypoglycemia in type 2 diabetes mellitus: the Diabetes Outcomes in Veterans Study (DOVES)
 Implications of diabetes in patients with acute coronary syndromes: the Global Registry of Acute Coronary Events
 Hostility and physiological risk in the National Heart, Lung, and Blood Institute Family Heart Study
 Diagnostic and therapeutic implications of relationships between fasting, 2-hour postchallenge plasma glucose and hemoglobin a1c values
 Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study
 Diabetic ketoacidosis in type 1 and type 2 diabetes mellitus: clinical and biochemical differences
 Sex differences in the effect of diabetes duration on coronary heart disease mortality
 Performance of screening questionnaires and risk scores for undiagnosed diabetes: the KORA Survey 2000
 Pulse oximetry as a potential screening tool for lower extremity arterial disease in asymptomatic patients with diabetes mellitus
 Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea
 Anemia with impaired erythropoietin response in diabetic patients
 Association of sleep time with diabetes mellitus and impaired glucose tolerance
 Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study
 Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus
 Marital quality and occurrence of the metabolic syndrome in women
 Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study
 Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome
 Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans
 Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
 Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospectively designed overviews of randomized trials
 Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study
 Plasma C peptide level and cognitive function among older women without diabetes mellitus
 Glycemic control and coronary heart disease risk in persons with and without diabetes: the atherosclerosis risk in communities study
 Risk factors for declining ankle-brachial index in men and women 65 years or older: the cardiovascular health study
 Reduced screening mammography among women with diabetes
 Direct, progressive association of cardiovascular risk factors with incident proteinuria: results from the Korea Medical Insurance Corporation (KMIC) study
 Disparities in diabetes care: impact of mental illness
 Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus
 An intervention to overcome clinical inertia and improve diabetes mellitus control in a primary care setting: Improving Primary Care of African Americans with Diabetes (IPCAAD) 8
 Type 2 diabetes mellitus in midlife estimated from the Cambridge Risk Score and body mass index
 Use of a blood glucose monitoring manual to enhance monitoring adherence in adults with diabetes: a randomized controlled trial
 Exogenous insulin use and hypertension in adult patients with type 2 diabetes mellitus
 Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women
 Mannose-binding lectin and mortality in type 2 diabetes
 Absolute and attributable risks of cardiovascular disease incidence in relation to optimal and borderline risk factors: comparison of African American with white subjects—Atherosclerosis Risk in Communities Study
 Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals: effect of differences in insulin sensitivity
 Longitudinal association between depressive symptoms and incident type 2 diabetes mellitus in older adults: the Cardiovascular Health Study
 Longitudinal incidence and prevalence of adverse outcomes of diabetes mellitus in elderly patients
 Helping patients with type 2 diabetes mellitus make treatment decisions: statin choice randomized trial
 Diabetes mellitus, glycemic control, and incident depressive symptoms among 70- to 79-year-old persons: the health, aging, and body composition study
 Associations of diabetes mellitus with total life expectancy and life expectancy with and without cardiovascular disease
 Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey
 Portion control plate for weight loss in obese patients with type 2 diabetes mellitus: a controlled clinical trial
 Low-dose rosiglitazone in patients with insulin-requiring type 2 diabetes
 Short-term variability in measures of glycemia and implications for the classification of diabetes
 A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women
 Mechanisms for racial and ethnic disparities in glycemic control in middle-aged and older Americans in the Health and Retirement Study
 Glycemic index, glycemic load, and cereal fiber intake and risk of type 2 diabetes in US black women
 Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women
 Inadequate control of hypertension in US adults with cardiovascular disease comorbidities in 2003-2004
 Survival benefit of nephrologic care in patients with diabetes mellitus and chronic kidney disease
 Clinic-based support to help overweight patients with type 2 diabetes increase physical activity and lose weight
 The growing burden of diabetes mellitus in the US elderly population—invited commentary
 Clinical outcomes by race in hypertensive patients with and without the metabolic syndrome: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
 Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years
 Development and validation of an all-cause mortality risk score in type 2 diabetes
 Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain
 Use of thiazolidinediones and fracture risk
 The impact of obesity on cardiovascular disease risk factors and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis
 Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study
 Physician performance and racial disparities in diabetes mellitus care
 Sugar-sweetened beverages and incidence of type 2 diabetes mellitus in African American women
 Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer—Norfolk prospective study
 Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial
 Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy
 Practice-linked online personal health records for type 2 diabetes mellitus: a randomized controlled trial
 Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects
 National trends in treatment of type 2 diabetes mellitus, 1994-2007
 Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy
 Poor glycemic control in diabetes and the risk of incident chronic kidney disease even in the absence of albuminuria and retinopathy: Atherosclerosis Risk in Communities (ARIC) Study
 Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes
 Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus
 Antipsychotic drugs and hyperglycemia in older patients with diabetes
 Thiazolidinediones and fractures in men and women
 Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: a report for the Childhood Cancer Survivor Study
 Neighborhood resources for physical activity and healthy foods and incidence of type 2 diabetes mellitus: the multi-ethnic study of atherosclerosis
 The effects of a nurse case manager and a community health worker team on diabetic control, emergency department visits, and hospitalizations among urban African Americans with type 2 diabetes mellitus: a randomized controlled trial
   British Medical Journal
 Are people with negative diabetes screening tests falsely reassured? Parallel group cohort study embedded in the ADDITION (Cambridge) randomised controlled trial
 Lifetime cost effectiveness of simvastatin in a range of risk groups and age groups derived from a randomised trial of 20,536 people
 Glycated haemoglobin (HbA1c) monitoring
 Prevention and early detection of vascular complications of diabetes
 Recent advances and emerging treatments
 Association of insulin resistance with depression: cross sectional findings from the British Women's Heart and Health Study
 Effects of low dose ramipril on cardiovascular and renal outcomes in patients with type 2 diabetes and raised excretion of urinary albumin: randomised, double blind, placebo controlled trial (the DIABHYCAR study)
 Prospective study of type 2 diabetes and cognitive decline in women aged 70-81 years
 Mortality in young people admitted to hospital for diabetes: database study
 Association of deprivation, ethnicity, and sex with quality indicators for diabetes: population based survey of 53,000 patients in primary care
 Insulin resistance and depression: cross sectional study
 Fatal liver failure associated with pioglitazone
 Sharing stories: complex intervention for diabetes education in minority ethnic groups who do not speak English
 Insulin resistance and depressive symptoms in middle aged men: findings from the Caerphilly prospective cohort study
 Use of waist circumference to predict insulin resistance: retrospective study
 Association of socioeconomic position with insulin resistance among children from Denmark, Estonia, and Portugal: cross sectional study
 Chronic stress at work and the metabolic syndrome: prospective study
 Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study
 Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study
 Effect of perioperative beta blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial
 Management of hyperglycaemia in type 2 diabetes: the end of recurrent failure?
 Impact of self monitoring of blood glucose in the management of patients with non-insulin treated diabetes: open parallel group randomised trial
 Psychological impact of screening for type 2 diabetes: controlled trial and comparative study embedded in the ADDITION (Cambridge) randomised controlled trial
 Patients' experiences of screening for type 2 diabetes: prospective qualitative study embedded in the ADDITION (Cambridge) randomised controlled trial
 Self monitoring of blood glucose in type 2 diabetes: longitudinal qualitative study of patients' perspectives
 Effectiveness of the Diabetes Education and Self Management for Ongoing and Newly Diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial
 Efficacy of self monitoring of blood glucose in patients with newly diagnosed type 2 diabetes (ESMON study): randomised controlled trial
 Cost effectiveness of self monitoring of blood glucose in patients with non-insulin treated type 2 diabetes: economic evaluation of data from the DiGEM trial
 Different strategies for screening and prevention of type 2 diabetes in adults: cost effectiveness analysis
 Management of retinal detachment: a guide for non-ophthalmologists
 Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study
 Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study
 The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease
 Predicting risk of type 2 diabetes in England and Wales: prospective derivation and validation of QDScore
 Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study
 Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial
 Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database
   Circulation
 Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD)
 Fish and long-chain omega-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women
 Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events
 Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
   Diabetes Care
 Clinical Practice Recommendations 2003 (Supplement)
 Effects of tadalafil on erectile dysfunction in men with diabetes
 Combination of insulin and metformin in the treatment of type 2 diabetes
 Optimal dose of candesartan for renoprotection in type 2 diabetic patients with nephropathy: a double-blind randomized cross-over study
 Randomized controlled community-based nutrition and exercise intervention improves glycemia and cardiovascular risk factors in type 2 diabetic patients in rural Costa Rica
 Diagnostic strategies to detect glucose intolerance in a multiethnic population
 Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects
 Acarbose improves glycemic control in overweight type 2 diabetic patients insufficiently treated with metformin
 Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study
 Randomized cross-over trial of insulin glargine plus lispro or NPH insulin plus regular human insulin in adolescents with type 1 diabetes on intensive insulin regimens
 A controlled trial of web-based diabetes disease management: the MGH diabetes primary care improvement project
 Impact of incident diabetes and incident nonfatal cardiovascular disease on 18-year mortality: the multiple risk factor intervention trial experience
 The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial
 Diabetes and abnormal glucose tolerance in women with previous gestational diabetes
 A comparison of diabetes education administered through telemedicine versus in person
 Increasing physical activity in people with type 2 diabetes
 Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial
 Systematic review of herbs and dietary supplements for glycemic control in diabetes
 Antihyperglycemic effect of oolong tea in type 2 diabetes
 Cost effectiveness of statin therapy for the primary prevention of major coronary events in individuals with type 2 diabetes
 The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis
 Effects of the early ACE inhibition in diabetic nonthrombolyzed patients with anterior acute myocardial infarction
 Human epidermal growth factor enhances healing of diabetic foot ulcers
 Evaluation of the impact of chiropodist care in the secondary prevention of foot ulcerations in diabetic subjects
 Management of dyslipidemia in children and adolescents with diabetes
 Evaluating concordance to American Diabetes Association standards of care for type 2 diabetes through group visits in an uninsured or inadequately insured patient population
 Specialist nurse-led intervention to treat and control hypertension and hyperlipidemia in diabetes (SPLINT): a randomized controlled trial
 Management of uncontrolled hypertension in a nurse-led clinic compared with conventional care for patients with type 2 diabetes
 Renoprotective effects of adding angiotensin II receptor blocker to maximal recommended doses of ACE inhibitor in diabetic nephropathy: a randomized double-blind crossover trial
 Biologic and quality-of-life outcomes from the Mediterranean Lifestyle Program: a randomized clinical trial
 Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials
 Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose: results from the LIPID trial
 HYAFF 11-based autologous dermal and epidermal grafts in the treatment of noninfected diabetic plantar and dorsal foot ulcers: a prospective, multicenter, controlled, randomized clinical trial
 Renin angiotensin aldosterone system blockade and renal disease in patients with type 2 diabetes: an Asian perspective from the RENAAL study
 Treatment of diabetic ketoacidosis with subcutaneous insulin aspart
   Diabetic Medicine
 Rosiglitazone in type 2 diabetes mellitus: an evaluation in British Indo-Asian patients
 Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents
   European Heart Journal
 Risks of cardiovascular events and effects of routine blood pressure lowering among patients with type 2 diabetes and atrial fibrillation: results of the ADVANCE study
   Experimental Biological Medicine
 Insulin resistance: cellular and clinical concepts
   Family Practice
 The North Dublin randomized controlled trial of structured diabetes shared care
   Journal of the American College of Cardiology
 Efficacy of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic dysfunction according to race, gender, and diabetic status: a meta-analysis of major clinical trials
   Journal of the American Medical Association
 Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial
 Midlife risk factors and healthy survival in men
 Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians
 Effects of quality improvement strategies for type 2 diabetes on glycemic control: a meta-regression analysis
 Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
 Role of the metabolic syndrome in risk assessment for coronary heart disease
 International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis
 Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus
 Using new insulin strategies in the outpatient treatment of diabetes: clinical applications
 Cost-effectiveness of intensive glycemic control, intensified hypertension control, and serum cholesterol level reduction for type 2 diabetes
 Association of health literacy with diabetes outcomes
 Nut and peanut butter consumption and risk of type 2 diabetes in women
 Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
 Effects of Internet behavioral counseling on weight loss in adults at risk for type 2 diabetes: a randomized trial
 Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus
 Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial
 Glucose control and mortality in critically ill patients
 Lifetime risk for diabetes mellitus in the United States
 Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes
 Body iron stores in relation to risk of type 2 diabetes in apparently healthy women
 Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women
 Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus
 Glucose metabolism and coronary heart disease in patients with normal glucose tolerance
 Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial
 The metabolic syndrome, inflammation, and risk of cognitive decline
 Trends in cardiovascular complications of diabetes
 Retinopathy and risk of congestive heart failure
 Fasting serum glucose level and cancer risk in Korean men and women
 Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women
 Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
 Relationship of physical activity vs body mass index with type 2 diabetes in women
 Influence of patient literacy on the effectiveness of a primary care-based diabetes disease management program
 Secular trends in cardiovascular disease risk factors according to body mass index in US adults
 Insulin resistance and risk of congestive heart failure
 High-risk patients with acute coronary syndromes treated with low-molecular-weight or unfractionated heparin: outcomes at 6 months and 1 year in the SYNERGY trial
 Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers
 Incidence of diabetes in youth in the United States
 Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis
 Diabetes and mortality following acute coronary syndromes
 Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial
 Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial
 Effect of lower targets for blood pressure and LDL cholesterol on atherosclerosis in diabetes: the SANDS randomized trial
 Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome
 A 40-year-old woman with diabetes contemplating pregnancy after gastric bypass surgery
 Ketosis-prone type 2 diabetes mellitus and human herpesvirus 8 infection in sub-Saharan Africans
 Examining a bidirectional association between depressive symptoms and diabetes
 Fetuin-A and incident diabetes mellitus in older persons
 Arsenic exposure and prevalence of type 2 diabetes in US adults
 Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial
 Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes
 Effect of a low-glycemic index or a high-cereal fiber diet on type 2 diabetes: a randomized trial
 Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial
 Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
 Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial
   Journal of the American Society of Nephrology
 Lowering blood pressure reduces renal events in type 2 diabetes
   Journal of Clinical Hypertension
 Type 2 diabetes: RENAAL and IDNT—the emergence of new treatment options
   Journal of Family Practice
 Starting insulin in type 2 diabetes: Continue oral hypoglycemic agents? A randomized trial in primary care
   Lancet
 Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial
 Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
 Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: comparative risk assessment
 Incidence of sight-threatening retinopathy in patients with type 2 diabetes in the Liverpool Diabetic Eye Study: a cohort study
 MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial
 Effect of losartan on sudden cardiac death in people with diabetes: data from the LIFE study
 Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
 Genetic cause of hyperglycaemia and response to treatment in diabetes
 Prevalence, care, and outcomes for patients with diet-controlled diabetes in general practice: cross sectional survey
 Cost-effectiveness of simvastatin in people at different levels of vascular disease risk: economic analysis of a randomised trial in 20,536 individuals
 Diabetes and associated disorders in Cambodia: two epidemiological surveys
 Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, double-blinded, multicentre trial
 Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial
 Early changes in the skin microcirculation and muscle metabolism of the diabetic foot
 The global burden of diabetic foot disease
 Treatment for diabetic foot ulcers
 Wound healing and its impairment in the diabetic foot
 Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes
 Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
 C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
 Aspirin resistance
 Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study
 Sexual dysfunction in men and women with endocrine disorders
 Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995-2005: a population-based study
 Renin-angiotensin system and cardiovascular risk
 Acute and chronic complications of type 2 diabetes mellitus in children and adolescents
 Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors
 Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial
 Depression, chronic diseases, and decrements in health: results from the World Health Surveys
 Efficacy of a theory-based behavioural intervention to increase physical activity in an at-risk group in primary care (ProActive UK): a randomised trial
 Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies
 Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial
 Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial
 Enhanced diabetes care to patients of south Asian ethnic origin (the United Kingdom Asian Diabetes Study): a cluster randomised controlled trial
 The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
 Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies
 Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
 Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial
 Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
 Effect of calcium dobesilate on occurrence of diabetic macular oedema (CALDIRET study): randomised, double-blind, placebo-controlled, multicentre trial
 Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance
 Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial
 Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
 Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
 Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
 Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study
 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study
   Metabolism
 Correlation between common carotid arterial wall thickness and ischemic stroke in patients with type 2 diabetes mellitus
   Morbidity and Mortality Weekly Report
 Self-reported prediabetes and risk-reduction activities—United States, 2006
   New England Journal of Medicine
 A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
 TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
 Homocysteine lowering with folic acid and B vitamins in vascular disease
 Intensive insulin therapy in the medical ICU
 Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus
 Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus
 Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
 Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
 Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood
 Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
 Preventing microalbuminuria in type 2 diabetes
 Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy
 Premature birth and later insulin resistance
 Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
 Insulin analogues
 Vascular risk factors and diabetic neuropathy
 Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis
 Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy
 Normal fasting plasma glucose levels and type 2 diabetes in young men
 Outpatient gatifloxacin therapy and dysglycemia in older adults
 Major congenital malformations after first-trimester exposure to ACE inhibitors
 Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
 Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations
 Clinical practice. Management of hyperglycemia in the hospital setting
 Inhaled insulin for diabetes mellitus
 Clinical practice. Diabetic gastroparesis
 Interleukin-1-receptor antagonist in type 2 diabetes mellitus
 Long-term effect of diabetes and its treatment on cognitive function
 Glucose regulation in young adults with very low birth weight
 Rosiglitazone evaluated for cardiovascular outcomes—an interim analysis
 Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes
 Effect of a multifactorial intervention on mortality in type 2 diabetes
 Telmisartan, ramipril, or both in patients at high risk for vascular events
 Aliskiren combined with losartan in type 2 diabetes and nephropathy
 Evaluation of the Framingham risk score in the European Prospective Investigation of Cancer-Norfolk cohort: does adding glycated hemoglobin improve the prediction of coronary heart disease events
 Long-term follow-up after tight control of blood pressure in type 2 diabetes
 10-year follow-up of intensive glucose control in type 2 diabetes
 Genotype score in addition to common risk factors for prediction of type 2 diabetes
 Clinical risk factors, DNA variants, and the development of type 2 diabetes
 Glucose control and vascular complications in veterans with type 2 diabetes
 Intensive versus conventional glucose control in critically ill patients
 A randomized trial of therapies for type 2 diabetes and coronary artery disease
 Sex hormone-binding globulin and risk of type 2 diabetes in women and men
 Three-year efficacy of complex insulin regimens in type 2 diabetes
 A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
   Pain
 Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy
   Stroke
 UKPDS 60: risk of stroke in type 2 diabetes estimated by the UK Prospective Diabetes Study risk engine
Review
   American Journal of Clinical Nutrition
 Glycemic index, glycemic load, and risk of type 2 diabetes
   Annals of Internal Medicine
 Narrative review: a rational approach to starting insulin therapy
 Screening for diabetic retinopathy
 Pharmacologic therapy for type 2 diabetes mellitus
 Nonhypoglycemic effects of thiazolidinediones
 Increased incidence of coronary atherosclerosis in type 2 diabetes mellitus: mechanisms and management
 Effect of alcohol consumption on diabetes mellitus: a systematic review
 Narrative review: hepatobiliary disease in type 2 diabetes mellitus
 Narrative review: ketosis-prone type 2 diabetes mellitus
 Meta-analysis: efficacy and safety of inhaled insulin therapy in adults with diabetes mellitus
 Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus
 Systematic review: comparative effectiveness and safety of premixed insulin analogues in type 2 diabetes
 Narrative review: effect of bariatric surgery on type 2 diabetes mellitus
 Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension
 Systematic review: glucose control and cardiovascular disease in type 2 diabetes
   Archives of Internal Medicine
 Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis
 Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis
 Clinical significance, pathogenesis, and management of postprandial hyperglycemia
 Combination therapy with angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists in the treatment of patients with type 2 diabetes mellitus
 Women and heart disease: the role of diabetes and hyperglycemia
 Postprandial glucose regulation and diabetic complications
 Comparative benefits of clopidogrel and aspirin in high-risk patient populations: lessons from the CAPRIE and CURE studies
 Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis
 Effectiveness of statin therapy in adults with coronary heart disease
 Treatment of hypertension in patients with diabetes
 Diabetes mellitus, the renin-angiotensin-aldosterone system, and the heart
 Systematic review and meta-analysis of short-acting insulin analogues in patients with diabetes mellitus
 Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis
 Cardiovascular outcomes in trials of oral diabetes medications: a systematic review
   British Medical Journal
 Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies
 Systematic review of lipid lowering for primary prevention of coronary heart disease in diabetes
 Systematic review of topical capsaicin for the treatment of chronic pain
 Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review
 Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: meta-analysis of randomised controlled trials
 Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis
 Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review
 Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?
 Artificially low HbA1c associated with treatment with ribavirin
 The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials
 Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials
   Clinical Evidence
 Glycaemic control in diabetes
 Cardiovascular disease in diabetes
 Foot ulcers and amputations in diabetes
 Diabetic retinopathy
   Cochrane Library
 Systems for routine surveillance for people with diabetes mellitus (Cochrane Review)
 Interventions to improve the management of diabetes mellitus in primary care, outpatient and community settings (Cochrane Review)
 Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus (Cochrane Review)
 Specialist nurses in diabetes mellitus (Cochrane Review)
 Hyperbaric oxygen therapy for chronic wounds (Cochrane Review)
 Dietary advice for treatment of type 2 diabetes mellitus in adults (Cochrane Review)
 Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus (Cochrane Review)
 Tramadol for neuropathic pain (Cochrane Review)
 Inhaled insulin in diabetes mellitus (Cochrane Review)
   Endocrinology
 Perspective: the search for genes for type 2 diabetes in the post-genome era
   Journal of the American Medical Association
 Assessing glycemia in diabetes using self-monitoring blood glucose and hemoglobin A1c
 Diabetes and atherosclerosis: epidemiology, pathophysiology, and management
 Molecular understanding of hyperglycemia's adverse effects for diabetic complications
 Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific review
 Preventing foot ulcers in patients with diabetes
 Diabetes and coronary revascularization
 Coffee consumption and risk of type 2 diabetes: a systematic review
 Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis
 Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
 Management of diabetic retinopathy: a systematic review
 Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials
 Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis
 Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis
 Patient-important outcomes in registered diabetes trials
 Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis
 Birth weight and risk of type 2 diabetes: a systematic review
 Diabetes in Asia: epidemiology, risk factors, and pathophysiology
 Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis
   Lancet
 Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis
 Systematic review and meta-analysis of randomised controlled trials of psychological interventions to improve glycaemic control in patients with type 2 diabetes
 Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis
 Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis
 Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies
 Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
 Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis
   New England Journal of Medicine
 Initial management of glycemia in type 2 diabetes mellitus
 Diverse causes of hypoglycemia-associated autonomic failure in diabetes
 Clinical practice. Neuropathic diabetic foot ulcers
 Cardiovascular risk and body-fat abnormalities in HIV-infected adults
 Thiazolidinediones
   Patient Education and Counseling
 A systematic review of psychosocial outcomes following education, self-management and psychological interventions in diabetes mellitus
Web
   American Association of Clinical Endocrinologists
 American College of Endocrinology Consensus Development Conference on Inpatient Diabetes and Metabolic Control
Commentary
   ACP Journal Club
      Diabetes mellitus
 2009 - Pioglitazone was associated with lower risk for adverse cardiovascular events than rosiglitazone in older patients
 2009 - A lifestyle intervention improved obstructive sleep apnea more than support and education in obese patients with diabetes
 2009 - A Mediterranean-style diet reduced need for glucose-lowering drugs more than a low-fat diet in type 2 diabetes
 2009 - Minimally invasive and conventional glucose monitoring did not differ for long-term glycemic control in insulin-treated diabetes
 2009 - Rosiglitazone was noninferior to metformin plus sulfonylurea for CV events but increased risk for HF and fractures in type 2 diabetes
 2009 - Review: Intensive glucose control reduced some CV events but did not change mortality in type 2 diabetes
 2009 - Bariatric surgery was cost-effective at 2 years for management of type 2 diabetes in obese patients
 2009 - Bariatric surgery was dominant over conventional therapy for lifetime management of type 2 diabetes in obese patients
 2008 - Review: Metformin reduces risk for CV mortality compared with other oral diabetes drugs or placebo in type 2 diabetes
 2008 - Intensive insulin therapy reduced long-term risk for incident hypertension in type 1 diabetes
 2008 - Benefits of early intensive glucose control to prevent diabetes complications were sustained for up to 10 years
 2008 - Benefits of tight blood pressure control to prevent diabetes complications were not sustained
 2008 - Glycemic control was not affected by self-monitoring of blood glucose in type 2 diabetes
 2008 - Self-monitoring of blood glucose was not cost-effective in non-insulin-treated type 2 diabetes
 2008 - Intensive insulin therapy improved glycemic control more than oral hypoglycemic agents in newly diagnosed type 2 diabetes
 2008 - Intensive glucose control did not prevent important complications in type 2 diabetes
 2008 - Intensive glucose control increased mortality and did not prevent cardiovascular events in type 2 diabetes
 2008 - Review: Little evidence exists on the benefits and harms of screening for and treating gestational diabetes
 2008 - A targeted, multifactorial intervention reduced mortality in patients with type 2 diabetes and microalbuminuria
 2008 - Adjustable gastric banding improved glycemic control in obese patients with type 2 diabetes
 2008 - Review: Statins prevent stroke and reduce mortality
 2007 - Thiazolidinediones increased risk for heart failure, myocardial infarction, and death in older patients with type 2 diabetes
 2007 - Aerobic plus resistance training was more effective than either alone for reducing HbA1c levels in type 2 diabetes
 - Review: Long-acting insulin analogues do not improve glycemic control but do reduce nocturnal hypoglycemia in diabetes
 2007 - Review: beta-blockers for hypertension increase risk for new-onset diabetes compared with nondiuretic antihypertensive agents
 2007 - Review: Thiazolidinediones increase congestive heart failure but not cardiovascular deaths in prediabetes or type 2 diabetes
 2007 - Self-monitoring of blood glucose did not improve glycemic control in patients with type 2 diabetes not treated with insulin
 2007 - Review: Incretin therapy improves glycemic control more than placebo in patients with type 2 diabetes
 2007 - Review: Thiazolidinediones increase risk for heart failure in type 2 diabetes
 2007 - Impaired fasting glucose and impaired glucose tolerance, as well as known diabetes, increased risk for death within 5 years
 2007 - Review: Meglitinide analogues reduce glucose levels in type 2 diabetes, but morbidity and mortality effects are unknown
 2007 - Review: Rosiglitazone increases risk for MI but does not differ from other drugs for CV death in type 2 diabetes
 2007 - Rosiglitazone increased heart failure but did not differ from metformin plus sulfonylurea for other CV outcomes at interim analysis
 2007 - A portion-control plate was effective for weight loss in obese patients with type 2 diabetes mellitus
 2007 - Review: Long-acting insulin analogues reduce risk for hypoglycemia compared with NPH insulin in type 2 diabetes
 2007 - Vildagliptin was effective as add-on therapy in type 2 diabetes inadequately controlled with metformin monotherapy
 2007 - Intensive insulin therapy during cardiac surgery did not reduce mortality or morbidity but increased risk for stroke
 2007 - Review: Angiotensin-receptor blockers and angiotensin-converting enzyme inhibitors have the lowest risk for diabetes
 2007 - Vildagliptin was noninferior to rosiglitazone for glycemic control in type 2 diabetes but caused less weight gain
 2006 - A lifestyle intervention continued to prevent type 2 diabetes in high-risk patients after the program was stopped
 2006 - Review: Inhaled insulin provides better glycemic control than oral hypoglycemic agents but not better than subcutaneous insulin
 2006 - Sitagliptin improved glycemic control and beta-cell function in type 2 diabetes
 2006 - Simvastatin was cost-effective across a broad range of risk and age groups
 2006 - Rosiglitazone reduced type 2 diabetes but increased heart failure in patients with impaired glycemic control
 2006 - Ramipril did not reduce incident diabetes in patients with impaired glycemic control
 2006 - Review: ACE inhibitors and angiotensin-receptor blockers reduce diabetes in hypertension and other CV risk factors
 2006 - Atorvastatin did not prevent cardiovascular events in type 2 diabetes
 2006 - Adjunctive inhaled insulin before meals improved glycemic control more than adjunctive metformin in type 2 diabetes mellitus
 2005 - Intensive insulin therapy reduced cardiovascular disease in type 1 diabetes
 2005 - Review: Angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers prevent type 2 diabetes
 2005 - Candesartan prevented development of diabetes mellitus in heart failure
 2005 - Screening and active management reduced perinatal complications more than routine care in gestational diabetes
 2005 - Review: alpha-Glucosidase inhibitors improve glycemic control but have uncertain effects on patient-important outcomes in type 2 diabetes
 2005 - A lifestyle intervention or metformin prevented or delayed the onset of the metabolic syndrome in persons at risk
 2005 - Review: Mixed signals from trials concerning pharmacologic prevention of type 2 diabetes mellitus
 2004 - Review: Insulin monotherapy and insulin combined with oral hypoglycemic agents provide similar glycemic control
 2004 - Review: Short-acting insulin analogues reduce glycosylated hemoglobin more than regular human insulin but only in adults with type 1 diabetes
 2005 - Diuretic-based therapy reduced cardiovascular mortality in older patients with isolated systolic hypertension and diabetes
 2004 - A dietitian-led intervention reduced weight and waist circumference in obese patients with type 2 diabetes
 2004 - Review: Fluoxetine, orlistat, and sibutramine modestly reduce weight in type 2 diabetes
 2003 - Review: Metformin does not increase risk for lactic acidosis or increase lactate levels in type 2 diabetes
 2003 - Review: Interventions focusing on patient behaviors in provider-patient interactions improve diabetes outcomes
 2003 - Acarbose reduced the risk for cardiovascular disease and hypertension in impaired glucose tolerance
 - Review: Rosiglitazone or pioglitazone as add-on therapy is effective for glycemic control in type 2 diabetes
 2003 - Enalapril reduced the risk for new-onset diabetes in left ventricular dysfunction
 2003 - A counseling strategy was better than usual care for adopting and maintaining physical activity in type 2 diabetes
 2003 - Combining fasting plasma glucose and glycosylated hemoglobin improved the accuracy for detecting patients with diabetes
 2002 - Training in flexible intensive insulin management improved glycemic control and quality of life in type 1 diabetes
 2002 - Losartan reduced cardiovascular morbidity and mortality more than atenolol in patients with diabetes and essential hypertension
 2002 - Review: Metformin does not increase fatal or nonfatal lactic acidosis or blood lactate levels in type 2 diabetes mellitus
 2002 - A split regimen of regular insulin at dinner and NPH insulin at bedtime reduced nocturnal hypoglycemia in type 1 diabetes
 2002 - A lifestyle intervention or metformin prevented or delayed the onset of type 2 diabetes in persons at risk
 2001 - Review: Stress hyperglycemia after ischemic stroke indicates a greater risk for death in patients without diabetes
 2001 - Several simple rules predicted complications in high-risk patients with diabetes
 2001 - Cardiovascular events were increased in high cardiovascular risk patients with albuminuria
 2001 - Changes in diet and physical activity prevented type 2 diabetes mellitus in persons with impaired glucose tolerance
 2001 - Review: Self-management training in type 2 diabetes mellitus is effective in the short term
 2000 - Glyburide was as safe and effective as insulin in gestational diabetes
 2000 - Review: Self-monitoring does not improve blood glucose control in type 2 diabetes mellitus

Educational Resources
Educational Syllabus
   Annual Session 2004: Updates
 Randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
 MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 5963 people with diabetes: a randomized controlled trial
 Inhaled insulin provides improved glycemic control in patients with type 2 diabetes mellitus inadequately controlled with oral agents
 Survival after pancreas transplantation in patients with diabetes and preserved kidney function
 Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study
 Dual blockade of the renin-angiotensin system versus maximal recommended dose of ACE inhibition in diabetic nephropathy
 Smoking is associated with renal impairment and proteinuria in the normal population: the AusDiab kidney study. Australian Diabetes, Obesity and Lifestyle Study
   Annual Session 2003: Updates
 General Internal Medicine: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
 Endocrinology: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
 Antimicrobial treatment in diabetic women with asymptomatic bacteriuria
 Prevalence of the metabolic syndrome among US adults. Findings from the Third National Health and Nutrition Examination Survey
   Annual Session 2002: Multiple Small Feedings of the Mind
 Diabetes Mellitus 2002
 Primary Care of the Patient with Hypertension
   Annual Session 2002: Updates
 Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance (the finish diabetes prevention group).
 Albuminuria and risk of cardiovascular events, death, and heat failure in diabetic and nondiabetic individuals (HOPE and MicroHOPE studies).
 Impact of diabetes on long-term survival after acute myocardial infarction (the Onset study): Comparability of risk with prior myocardial infarction.
 Diagnosing insulin resistance in the general population.
 Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes
 The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes
 Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy
   Clinical Problem-Solving Cases
 58-year-old man with burning, pain and numbness of feet and hands
   MKSAP 12
 Diabetes Mellitus
Book Chapter
   Medical Care of the Pregnant Patient
 Type 1 and Type 2 Diabetes

Patient Information
Web
 Agency for Healthcare Research and Quality: Premixed Insulin for Type 2 Diabetes: A Guide for Adults
 American College of Physicians: ACP Special Report: Managing the ABCs of Diabetes
 American College of Physicians: Diabetes: America's Hidden Killer
 American College of Physicians: Five Keys to a Healthy Heart: A Guide for African Americans
 American College of Physicians: Living With Diabetes: A Guide for African Americans
 American College of Physicians Foundation HEALTH TiPS: Diabetes
 Annals of Internal Medicine: Summaries for Patients: Blood Pressure Control in People with Type 2 Diabetes Mellitus: Recommendations from the American College of Physicians
 National Diabetes Education Program: Take Care of Your Feet for a Lifetime
 National Eye Institute: Don't Lose Sight of Diabetic Eye Disease
 National Eye Institute: Diabetic Retinopathy: What You Should Know
 National Eye Institute: Diabetic Eye Disease: How Much Do You Know?
 National Institute for Diabetes and Digestive and Kidney Diseases: Alternative Devices for Taking Insulin
 National Institute of Diabetes and Digestive and Kidney Diseases: Diabetes Overview
 National Institute of Diabetes and Digestive and Kidney Diseases: Diagnosis of Diabetes
 National Institute of Diabetes and Digestive and Kidney Diseases: Kidney Disease of Diabetes
 National Institute of Diabetes and Digestive and Kidney Diseases: Medicines for People with Diabetes
 National Institute of Diabetes and Digestive and Kidney Diseases: What I Need to Know About Eating and Diabetes
 National Institute of Diabetes and Digestive and Kidney Diseases: Your Guide to Diabetes: Type 1 and Type 2
 U.S. Food and Drug Administration: Quick Information-Diabetes
 American College of Physicians: Diabetes: Prevention and Control: A Guide for Hispanic Americans (Spanish)
 National Diabetes Education Program: Take Care of Your Feet for a Lifetime (Spanish)
 National Eye Institute: Diabetic Eye Disease: How Much Do You Know? (Spanish)
 National Institute for Diabetes and Digestive and Kidney Diseases: Control Your Diabetes for Life: Tips for Feeling Better and Staying Healthy (Spanish)
 National Institute of Diabetes and Digestive and Kidney Diseases: Keep Your Kidneys Healthy (Spanish)
 National Institute of Diabetes and Digestive and Kidney Diseases: Medicines for People With Diabetes (Spanish)
 National Institute of Diabetes and Digestive and Kidney Diseases: What I Need to Know About Eating and Diabetes (Spanish)
 National Institute of Diabetes and Digestive and Kidney Diseases: Your Guide to Diabetes: Type 1 and Type 2 (Spanish)
 U.S. Food and Drug Administration: Quick Information-Diabetes (Spanish)
FAQs | Patient Information
Sandeep Vijan, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Darren B. Taichman, MD, PhD, Editor, PIER, has received grant support from Actelion Pharmaceuticals Ltd , and honoraria for continuing medical education grand rounds and lectures given.


The information included herein should never be used as a substitute for clinical judgment and does not represent an official position of ACP. Because all PIER modules are updated regularly, printed web pages or PDFs may rapidly become obsolete. Therefore, PIER users should compare the date of the last update on the website with any printout to ensure that the information being referred to is the most current available.
PIER is copyrighted (c) 2010 by the American College of Physicians,
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