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Rationale:
- Treatment of concomitant risk decreases the risk of coronary events.
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Evidence:
- Within 8 years after diagnosis, as many as 45% of patients experience macrovascular complications of diabetes (171).
- Cardiovascular complications—the most common advanced complications associated with type 2 diabetes—account for 50% to 60%
of all diabetes-related mortality (172; 173).
- Modification of macrovascular risk factors can reduce risk of disease. Aggressive hypertension control, in particular, has
been shown to reduce macrovascular event rates (26).
- Patients with diabetes have mortality rates almost twice that of the general population (174; 175; 176).
- Younger patients, in particular, have high excess mortality; the incremental mortality risk seems to decrease with older age
of onset (25; 177).
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Comments:
- Although educational interventions have been proven effective as a whole, individualized components (e.g., explaining the
incidence of macrovascular disease) have not been well evaluated.
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Sandeep Vijan, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Darren B. Taichman, MD, PhD, Editor, PIER, has received grant support from Actelion Pharmaceuticals Ltd , and honoraria for
continuing medical education grand rounds and lectures given.
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for clinical judgment and does not represent an official position of
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compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2010 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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