Acute Viral Conjunctivitis Author: Stephen Orlin, MD
Module updated - 2008-04-08
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Diagnosis
  • Take a careful history to confirm the diagnosis of viral conjunctivitis.
  • Perform a basic eye examination.
  • Use selected tests to assist in the differential diagnosis of unusual forms of conjunctivitis.
  • Consider other causes of conjunctival inflammation.
History and Physical Examination Elements for Viral Conjunctivitis (table)
Laboratory and Other Studies for Conjunctivitis (table)
Differential Diagnosis of Acute Viral Conjunctivitis (table)


Take a careful history to confirm the diagnosis of viral conjunctivitis. C

  • Ask about:
    • Itching
    • Onset and duration of symptoms in each affected eye
    • Watery or mucoid discharge
    • Sticking together of lids
    • Ocular pain and discomfort
    • Foreign body sensation
    • Light sensitivity
    • Blurred vision
    • Similar eye infection in family members or other close contacts
    • Upper respiratory symptoms
    • Headache
    • Muscle weakness
    • Use of contact lenses
    • History of rheumatologic disease
  • See table History and Physical Examination Elements for Viral Conjunctivitis.
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Perform a basic eye examination. C

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Use selected tests to assist in the differential diagnosis of unusual forms of conjunctivitis. BC

  • Consider obtaining:
    • Rapid, point-of-care immunoassays to detect adenovirus
    • Cytology specimen of conjunctival epithelium, which may show intracytoplasmic inclusions in suspected chlamydial conjunctivitis
    • PCR to screen for chlamydia, atypical HSV, or adenovirus
    • Cytology specimen, which may show eosinophilia in suspected allergic conjunctivitis
    • Culture of the conjunctiva in suspected chlamydia or herpes virus
    • Bacterial culture if there is purulent discharge, particularly in patients with hyperacute purulent conjunctivitis, which may reveal N. gonorrhea
    • Conjunctival biopsy specimen in patients with suspected sarcoid and ocular cicatricial pemphigoid
  • See table Laboratory and Other Studies for Conjunctivitis.
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Consider other causes of conjunctival inflammation. C

  • In the differential diagnosis of adenoviral conjunctivitis, consider:
    • Bacterial conjunctivitis
    • Other viral causes (herpes simplex, herpes zoster, enterovirus, coxsackievirus, molluscum contagiosum)
    • Chlamydia trachomatis
    • Allergic conjunctivitis
    • Sexually transmitted conjunctivitis (e.g., chlamydia, herpes, gonorrhea, syphilis, and HIV)
    • Other inflammatory causes of conjunctivitis (e.g., sarcoid, superior limbic keratoconjunctivitis, cat scratch disease)
    • Episcleritis and scleritis
    • Blepharitis
    • Dry eyes
  • See table Differential Diagnosis of Acute Viral Conjunctivitis.
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FAQs
Robert Sambursky, MD, editorial consultant, Chief Medical Officer for Rapid Pathogen Screening, Inc.;served as consultant for Rapid Pathogen Screening, Inc.;received an honoraria for Rapid Pathogen Screening, Inc.;serves as consultant for Rapid Pathogen Screening, Inc; owns stock options in Rapid Pathogen Screening, Inc.;served as board member or director for Rapid Pathogen Screening, Inc.;received grants and has grants pending from Rapid Pathogen Screening, Inc.;and has received patents and has patents pending for Rapid Pathogen Screening, Inc. Stephen Orlin, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Steven E. Weinberger, MD, FACP, Acting Editor, PIER, has stock holdings in Glaxosmithkline and Abbott.


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