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Anthrax > Follow-up Author: Sandro Cinti, MD; Barbara Robinson-Dunn, PhD; Niklas Mackler, MD
Editorial changes - 2008-10-10
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Rationale:

  • Patients may develop disease if a full course (60 days) of prophylactic antibiotics is not taken.
  • Ciprofloxacin and doxycycline can cause side effects and laboratory abnormalities.
  • Aggressive diagnostic and treatment strategies are warranted in patients exposed to anthrax during an outbreak.

Evidence:

  • Anthrax spores were detected in the lung parenchyma of rhesus monkeys 100 days after exposure (17).
  • During the recent anthrax outbreak, no postal workers who received prophylaxis developed anthrax (15).
  • Ciprofloxacin and doxycycline can cause rashes, gastrointestinal symptoms, and liver toxicity (54; 55).
  • Data collected during a postexposure antiobiotic prophylaxis campaign showed that adherence to a full 60-day course of antibiotic therapy was only approximately 44%. Poor adherence was not necessarily related to adverse events (19).

Comments:

  • None.
FAQs
Barbara Robinson-Dunn, PhD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Demetrios N. Kyriacou, MD, PhD, editorial consultant, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Niklas Mackler, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Sandro Cinti, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.

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