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West Nile Virus Disease > Drug Therapy Author: Amy V. Bode, MD, MSPH; James J. Sejvar, MD; Anthony A. Marfin, MD, MPH
Editorial changes - 2008-08-28
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Rationale:

  • These agents have been helpful in the treatment of cerebral edema.

Evidence:

  • The potential benefit of short-course, high-dose corticosteroids must be weighed against the theoretical risk of potentiating the viral infection according to expert opinion (6).
  • The use of steroids in the absence of edema or impending herniation did not change the outcomes of children with acute Japanese encephalitis, a closely related flavivirus (44).

Comments:

  • The role of these agents in the treatment of WNV and related flaviviruses is uncertain. Potential enhancement of the viral burden must be considered.

FAQs
Amy V. Bode, MD, MSPH has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Anthony A. Marfin, MD, MPH has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Carrie Nielsen, PhD, editorial consultant, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. James J. Sejvar, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.


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