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Rationale:
- Some patients may develop new or recurrent neuropsychiatric symptoms after initial symptoms resolve, which are thought to
result from delayed neuron death.
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Evidence:
- Observation of 2306 patients showed 65 (2.75%) to have delayed-onset neurologic symptoms a mean of 22 days postexposure (50).
- An observational case series of 21 patients showed that the 11 patients with persistent CT abnormalities in the globus pallidus
had worse outcomes when compared with the 10 poisoned patients with normal CT scans at 3-month follow-up (53).
- Observation of 23 patients with delayed-onset symptoms showed that 61% later improved to normal, 26% had persistent abnormalities,
and 13% died (51).
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Comments:
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Jeffrey T. Chapman, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Steven E. Weinberger, MD, FACP, Acting Editor, PIER, has stock holdings in Glaxosmithkline and Abbott.
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The information included herein should never be used as a substitute
for clinical judgment and does not represent an official position of
ACP. Because all PIER modules are updated regularly, printed web pages
or PDFs may rapidly become obsolete. Therefore, PIER users should
compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2009 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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Carbon Monoxide Poisoning
> Follow-up
