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Rationale:
- CO binds to hemoglobin with 200 to 250 times the affinity of molecular oxygen and also binds tightly to intracellular heme
proteins.
- Increasing the PO 2 in the blood and peripheral tissue via NBOT therapy enhances the dissociation of CO, which is then eliminated by exhalation.
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Evidence:
- Facemask-delivered 100% oxygen reduces the half-life of CO in blood from 2 to 4 hours to approximately 74 minutes (43).
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Comments:
- Side effects of NBOT are minimal and limited to mild ventilatory suppression in patients with severe obstructive lung disease
and discomfort of delivery via facemask.
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Jeffrey T. Chapman, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Steven E. Weinberger, MD, FACP, Acting Editor, PIER, has stock holdings in Glaxosmithkline and Abbott.
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The information included herein should never be used as a substitute
for clinical judgment and does not represent an official position of
ACP. Because all PIER modules are updated regularly, printed web pages
or PDFs may rapidly become obsolete. Therefore, PIER users should
compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2009 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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Carbon Monoxide Poisoning
> Non-drug Therapy
