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- Use NBOT as the primary treatment of CO poisoning.
- Consider using HBOT in specific circumstances.
- Provide supportive care as needed.
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Use NBOT as the primary treatment of CO poisoning.  |
- Intubate patients who are unable to protect their airway or who are at risk for aspiration because of impaired neurologic status and ventilate with 100% oxygen.
- Treat all patients with normobaric supplemental oxygen via a nonrebreathing facemask as soon as a diagnosis of CO poisoning is entertained and while evaluating the severity of the poisoning and concurrent illnesses.
- In patients with moderately elevated HbCO (between 5% and 25%) and only nausea, treat with oxygen for 6 hours and then reassess and discharge if symptoms have abated and HbCO has normalized.
- In patients with moderately elevated HbCO and other symptoms, treat with NBOT and admit to the hospital for overnight observation and therapy.
- Admit patients with symptoms related to CO toxicity but normal HbCO (less than 5%) who may have ongoing cellular ischemia and treat with NBOT until symptoms resolve or another cause is defined.
- Discontinue supplemental oxygen therapy and discharge admitted patients once symptoms resolve.
| Background | Back to top
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Consider using HBOT in specific circumstances.  |
- Although controversial, consider using HBOT to treat patients with severe CO poisoning (defined as HbCO greater than 25%), loss of consciousness, persistent neurologic deficit other than nausea or headache, or evidence of cardiac ischemia.
- Treat all pregnant patients, comatose patients, and possibly children with HBOT.
- Although no treatment protocol has been proven best, if HBOT is deemed necessary, use 100% oxygen at 2 to 3 atmospheres for 120-minute periods until symptoms have resolved and HbCO is normal.
- Monitor for side effects such as seizures, tympanic membrane damage, and claustrophobia during HBOT.
| Background | Back to top
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Provide supportive care as needed.  |
- Intubate patients with decreased mental status who are unable to maintain a safe airway or have ventilatory compromise and place them on mechanical ventilation.
- Provide chronotropic support with transvenous pacing in patients with bradycardia unresponsive to standard medical therapy.
| Background | Back to top
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| Jeffrey T. Chapman, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Steven E. Weinberger, MD, FACP, Acting Editor, PIER, has stock holdings in Glaxosmithkline and Abbott. |
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