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Rationale:
- Most patients recover fully, but some have persistent or delayed-onset neurologic dysfunction.
- Animal research suggests the dysfunction is secondary to central nervous system toxicity and possibly delayed cell death or
apoptosis.
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Evidence:
- An observational study showed that 67% of 307 poisoned patients had full recovery but that all patients recovered enough neurologic
function to return to their former occupation (42).
- An observational study of 32 patients did not show delayed-onset memory abnormalities in patients (49).
- Observation of 2306 patients showed 65 (2.75%) to have delayed-onset neurologic symptoms a mean of 22 days postexposure (50).
- Observation of 23 patients with delayed-onset symptoms showed that 61% later improved to normal, 26% had persistent abnormalities,
and 13% died (51).
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Comments:
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Jeffrey T. Chapman, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Steven E. Weinberger, MD, FACP, Acting Editor, PIER, has stock holdings in Glaxosmithkline and Abbott.
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The information included herein should never be used as a substitute
for clinical judgment and does not represent an official position of
ACP. Because all PIER modules are updated regularly, printed web pages
or PDFs may rapidly become obsolete. Therefore, PIER users should
compare the date of the last update on the website with any printout
to ensure that the information being referred to is the most current
available.
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PIER is copyrighted (c) 2009 by the American College of Physicians,
190 N. Independence Mall West, Philadelphia, PA 19106-1572, USA.
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Carbon Monoxide Poisoning
> Patient Education
