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Carbon Monoxide Poisoning > Patient Education Author: Jeffrey T. Chapman, MD
Editorial changes - 2009-11-30
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Rationale:

  • Most patients recover fully, but some have persistent or delayed-onset neurologic dysfunction.
  • Animal research suggests the dysfunction is secondary to central nervous system toxicity and possibly delayed cell death or apoptosis.

Evidence:

  • An observational study showed that 67% of 307 poisoned patients had full recovery but that all patients recovered enough neurologic function to return to their former occupation (42).
  • An observational study of 32 patients did not show delayed-onset memory abnormalities in patients (49).
  • Observation of 2306 patients showed 65 (2.75%) to have delayed-onset neurologic symptoms a mean of 22 days postexposure (50).
  • Observation of 23 patients with delayed-onset symptoms showed that 61% later improved to normal, 26% had persistent abnormalities, and 13% died (51).

Comments:

  • None.
FAQs
Jeffrey T. Chapman, MD has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.
Deborah Korenstein, MD, FACP, Co-Editor, PIER, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations. Richard B. Lynn, MD, FACP, Co-Editor, PIER, has no financial relationships with pharmaceutical companies, biomedical device manufacturers, or health-care related organizations.

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